Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa)    
Predicted Functional Partners:
TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.
    
 0.999
TRAF6
TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]
   
 0.999
MAP3K7
Mitogen-activated protein kinase kinase kinase 7.
   
 0.999
TAB3
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3.
    
 0.999
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.996
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.986
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.983
RIPK2
Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.
   
 0.982
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.
    
 0.979
XIAP
X-linked inhibitor of apoptosis.
   
 0.978
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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