Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TRIM10Tripartite motif-containing 10. (481 aa)    
Predicted Functional Partners:
TRIM44
Tripartite motif containing 44.
    
 
 0.794
ZSCAN23
Zinc finger and SCAN domain containing 23.
    
 0.779
TRIM35
Tripartite motif-containing protein 35 isoform 2.
   
 
 0.726
GYPA
Glycophorin.
   
  
 0.695
PPP1R11
E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
      
 0.682
POU5F1
POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency; Belongs to the POU transcription factor family. Class-5 subfamily.
    
 0.625
FAM193B
FAM193_C domain-containing protein.
    
  0.616
ANKRD11
Ankyrin repeat domain 11.
    
 0.601
KEL
Kell metallo-endopeptidase (Kell blood group).
   
    0.577
H1-3
Histone H1.3.
    
 
 0.575
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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