Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)    
Predicted Functional Partners:
TRAF6
TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]
   
 0.997
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.994
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.990
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.
    
 0.990
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.984
BCL3
BCL3 transcription coactivator.
   
 0.983
SPATA2
Spermatogenesis-associated protein PD1.
     
 0.982
SQSTM1
Sequestosome 1.
    
 0.982
TNFRSF1A
TNF receptor superfamily member 1A.
    
 0.977
RNF31
Uncharacterized protein.
    
 0.969
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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