IGF1R protein (Macaca mulatta) - STRING interaction network

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[Homology]

Score

IGF1R

Tyrosine-protein kinase receptor. (1367 aa)

Predicted Functional Partners:

IGF1

0.999

IRS1

0.997

GRB10

0.996

INS

0.996

SHC1

0.995

INSR

0.994

IRS2

0.988

IGF2

0.985

PIK3CA

0.984

PIK3R1

0.984

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB10	IGF1	ENSMMUP00000026288	ENSMMUP00000002988	Uncharacterized protein.	Insulin like growth factor 1.	0.457
GRB10	IGF1R	ENSMMUP00000026288	ENSMMUP00000016141	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.996
GRB10	IGF2	ENSMMUP00000026288	ENSMMUP00000075297	Uncharacterized protein.	Insulin like growth factor 2.	0.547
GRB10	INS	ENSMMUP00000026288	ENSMMUP00000037777	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.611
GRB10	INSR	ENSMMUP00000026288	ENSMMUP00000045695	Uncharacterized protein.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.997
GRB10	IRS1	ENSMMUP00000026288	ENSMMUP00000045227	Uncharacterized protein.	Insulin receptor substrate 1.	0.792
GRB10	IRS2	ENSMMUP00000026288	ENSMMUP00000028694	Uncharacterized protein.	Insulin receptor substrate 2.	0.743
GRB10	PIK3CA	ENSMMUP00000026288	ENSMMUP00000006866	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.920
GRB10	PIK3R1	ENSMMUP00000026288	ENSMMUP00000015140	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.956
GRB10	SHC1	ENSMMUP00000026288	ENSMMUP00000008658	Uncharacterized protein.	SHC-transforming protein 1 isoform 3.	0.486
IGF1	GRB10	ENSMMUP00000002988	ENSMMUP00000026288	Insulin like growth factor 1.	Uncharacterized protein.	0.457
IGF1	IGF1R	ENSMMUP00000002988	ENSMMUP00000016141	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.999
IGF1	IGF2	ENSMMUP00000002988	ENSMMUP00000075297	Insulin like growth factor 1.	Insulin like growth factor 2.	0.956
IGF1	INS	ENSMMUP00000002988	ENSMMUP00000037777	Insulin like growth factor 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.992
IGF1	INSR	ENSMMUP00000002988	ENSMMUP00000045695	Insulin like growth factor 1.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.997
IGF1	IRS1	ENSMMUP00000002988	ENSMMUP00000045227	Insulin like growth factor 1.	Insulin receptor substrate 1.	0.891
IGF1	IRS2	ENSMMUP00000002988	ENSMMUP00000028694	Insulin like growth factor 1.	Insulin receptor substrate 2.	0.820
IGF1	PIK3CA	ENSMMUP00000002988	ENSMMUP00000006866	Insulin like growth factor 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.578
IGF1	PIK3R1	ENSMMUP00000002988	ENSMMUP00000015140	Insulin like growth factor 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.450
IGF1	SHC1	ENSMMUP00000002988	ENSMMUP00000008658	Insulin like growth factor 1.	SHC-transforming protein 1 isoform 3.	0.585