Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TRIB3Tribbles pseudokinase 3. (385 aa)    
Predicted Functional Partners:
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
0.993
AKT2
AKT serine/threonine kinase 2.
    
0.981
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
0.979
PPARA
Peroxisome proliferator activated receptor alpha.
    
 0.934
ATF4
BZIP domain-containing protein.
   
 0.925
COP1
Uncharacterized protein.
    
 
 0.915
STK40
Serine/threonine-protein kinase 40.
    
 
 0.911
CHAC1
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
   
 
 0.901
ATF5
Activating transcription factor 5.
   
 0.799
TAOK3
TAO kinase 3.
      
 0.769
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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