UHRF1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

UHRF1

Ubiquitin like with PHD and ring finger domains 1. (795 aa)

Predicted Functional Partners:

DNMT1

0.996

H3-4

0.950

HDAC1

0.933

USP7

0.929

UBE2D3

0.928

KAT5

0.920

COX14

0.918

DPPA3

0.916

PCLAF

0.901

LIG1

0.858

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX14	UHRF1	ENSMMUP00000064637	ENSMMUP00000016682	Stella-related protein.	Ubiquitin like with PHD and ring finger domains 1.	0.918
DNMT1	H3-4	ENSMMUP00000019170	ENSMMUP00000065118	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.898
DNMT1	HDAC1	ENSMMUP00000019170	ENSMMUP00000013015	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.988
DNMT1	KAT5	ENSMMUP00000019170	ENSMMUP00000026085	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.658
DNMT1	LIG1	ENSMMUP00000019170	ENSMMUP00000069832	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA ligase.	0.627
DNMT1	UHRF1	ENSMMUP00000019170	ENSMMUP00000016682	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin like with PHD and ring finger domains 1.	0.996
DNMT1	USP7	ENSMMUP00000019170	ENSMMUP00000005427	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.926
DPPA3	UHRF1	ENSMMUP00000068805	ENSMMUP00000016682	Uncharacterized protein.	Ubiquitin like with PHD and ring finger domains 1.	0.916
H3-4	DNMT1	ENSMMUP00000065118	ENSMMUP00000019170	Histone H3; Belongs to the histone H3 family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.898
H3-4	HDAC1	ENSMMUP00000065118	ENSMMUP00000013015	Histone H3; Belongs to the histone H3 family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.871
H3-4	KAT5	ENSMMUP00000065118	ENSMMUP00000026085	Histone H3; Belongs to the histone H3 family.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.544
H3-4	UHRF1	ENSMMUP00000065118	ENSMMUP00000016682	Histone H3; Belongs to the histone H3 family.	Ubiquitin like with PHD and ring finger domains 1.	0.950
HDAC1	DNMT1	ENSMMUP00000013015	ENSMMUP00000019170	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.988
HDAC1	H3-4	ENSMMUP00000013015	ENSMMUP00000065118	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone H3; Belongs to the histone H3 family.	0.871
HDAC1	KAT5	ENSMMUP00000013015	ENSMMUP00000026085	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.696
HDAC1	UHRF1	ENSMMUP00000013015	ENSMMUP00000016682	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Ubiquitin like with PHD and ring finger domains 1.	0.933
HDAC1	USP7	ENSMMUP00000013015	ENSMMUP00000005427	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.649
KAT5	DNMT1	ENSMMUP00000026085	ENSMMUP00000019170	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.658
KAT5	H3-4	ENSMMUP00000026085	ENSMMUP00000065118	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Histone H3; Belongs to the histone H3 family.	0.544
KAT5	HDAC1	ENSMMUP00000026085	ENSMMUP00000013015	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.696