Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
PDIA6Uncharacterized protein; Belongs to the protein disulfide isomerase family. (492 aa)    
Predicted Functional Partners:
HSPA5
78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.
   
 0.993
P4HB
Protein disulfide-isomerase.
  
0.959
DNAJC3
Interferon-induced, double-stranded RNA-activated protein kinase inhibitor.
   
 0.953
ERO1A
Endoplasmic reticulum oxidoreductase 1 alpha.
   
 0.953
CALR
Calreticulin.
   
 0.952
ERO1B
Uncharacterized protein.
   
 0.951
HSP90B1
Endoplasmin.
   
 0.950
PDIA4
Protein disulfide-isomerase A4.
   
0.936
RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]
   
 
 0.925
PDIA3
Protein disulfide-isomerase.
   
0.916
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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