| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFLAR | ITCH | ENSMMUP00000073792 | ENSMMUP00000016958 | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. | E3 ubiquitin-protein ligase. | 0.992 |
| CFLAR | WWP1 | ENSMMUP00000073792 | ENSMMUP00000062623 | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. | E3 ubiquitin-protein ligase. | 0.504 |
| ITCH | CFLAR | ENSMMUP00000016958 | ENSMMUP00000073792 | E3 ubiquitin-protein ligase. | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. | 0.992 |
| ITCH | MAPK10 | ENSMMUP00000016958 | ENSMMUP00000042171 | E3 ubiquitin-protein ligase. | Mitogen-activated protein kinase. | 0.953 |
| ITCH | NOTCH1 | ENSMMUP00000016958 | ENSMMUP00000022401 | E3 ubiquitin-protein ligase. | Notch receptor 1. | 0.977 |
| ITCH | NOTCH2 | ENSMMUP00000016958 | ENSMMUP00000046517 | E3 ubiquitin-protein ligase. | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. | 0.938 |
| ITCH | NOTCH3 | ENSMMUP00000016958 | ENSMMUP00000017928 | E3 ubiquitin-protein ligase. | Notch receptor 3. | 0.939 |
| ITCH | NUMB | ENSMMUP00000016958 | ENSMMUP00000043487 | E3 ubiquitin-protein ligase. | NUMB endocytic adaptor protein. | 0.953 |
| ITCH | RNF11 | ENSMMUP00000016958 | ENSMMUP00000064103 | E3 ubiquitin-protein ligase. | Ring finger protein 11. | 0.950 |
| ITCH | TP63 | ENSMMUP00000016958 | ENSMMUP00000038274 | E3 ubiquitin-protein ligase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.959 |
| ITCH | TP73 | ENSMMUP00000016958 | ENSMMUP00000021769 | E3 ubiquitin-protein ligase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.941 |
| ITCH | WWP1 | ENSMMUP00000016958 | ENSMMUP00000062623 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase. | 0.947 |
| MAPK10 | ITCH | ENSMMUP00000042171 | ENSMMUP00000016958 | Mitogen-activated protein kinase. | E3 ubiquitin-protein ligase. | 0.953 |
| MAPK10 | TP63 | ENSMMUP00000042171 | ENSMMUP00000038274 | Mitogen-activated protein kinase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.414 |
| MAPK10 | TP73 | ENSMMUP00000042171 | ENSMMUP00000021769 | Mitogen-activated protein kinase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.414 |
| NOTCH1 | ITCH | ENSMMUP00000022401 | ENSMMUP00000016958 | Notch receptor 1. | E3 ubiquitin-protein ligase. | 0.977 |
| NOTCH1 | NOTCH2 | ENSMMUP00000022401 | ENSMMUP00000046517 | Notch receptor 1. | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. | 0.983 |
| NOTCH1 | NOTCH3 | ENSMMUP00000022401 | ENSMMUP00000017928 | Notch receptor 1. | Notch receptor 3. | 0.868 |
| NOTCH1 | NUMB | ENSMMUP00000022401 | ENSMMUP00000043487 | Notch receptor 1. | NUMB endocytic adaptor protein. | 0.987 |
| NOTCH1 | WWP1 | ENSMMUP00000022401 | ENSMMUP00000062623 | Notch receptor 1. | E3 ubiquitin-protein ligase. | 0.596 |
