STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STIP1Uncharacterized protein. (590 aa)    
Predicted Functional Partners:
SLC29A1
HATPase_c domain-containing protein.
   
 0.989
HSP90AA1
HATPase_c domain-containing protein.
   
 0.984
PRNP
Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]
    
 0.974
HSPA8
Heat shock cognate 71 kDa protein isoform 1; Belongs to the heat shock protein 70 family.
   
 0.960
LOC709412
Uncharacterized protein; Belongs to the heat shock protein 70 family.
   
 0.940
HSPA4
Heat shock protein family A (Hsp70) member 4.
   
 0.938
CRMP1
Amidohydro-rel domain-containing protein.
    
 
 0.931
AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1.
   
 
 0.930
TSC1
TSC complex subunit 1.
   
 0.925
NR3C1
Nuclear receptor subfamily 3 group C member 1.
   
 0.912
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.