Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (579 aa)    
Predicted Functional Partners:
SIX5
SIX homeobox 5.
   
 0.840
ARL13A
ADP ribosylation factor like GTPase 13A.
      
 0.806
SIX1
SIX homeobox 1.
   
 0.798
PPP2R2A
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.
    
 
 0.726
HSPB7
Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family.
      
 0.724
SIX4
SIX homeobox 4.
   
 0.699
SIX2
SIX homeobox 2.
   
 0.698
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
      
 0.667
PPP2CB
Serine/threonine-protein phosphatase.
    
   0.650
DACH1
Dachshund family transcription factor 1.
    
 
 0.633
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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