Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
FBXL17F-box and leucine rich repeat protein 17. (702 aa)    
Predicted Functional Partners:
BACH1
Uncharacterized protein.
    
  0.977
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.961
KLHL12
BTB domain-containing protein.
    
 0.939
SKP1-2
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.893
BACH2
BTB domain and CNC homolog 2.
    
  0.873
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 
 0.797
RBX1
E3 ubiquitin-protein ligase RBX1.
    
 0.785
SGCZ
Sarcoglycan zeta.
      
 0.769
KLHL28
BTB domain-containing protein.
    
 0.738
ZBTB18
Zinc finger protein 238 isoform 1.
    
   0.728
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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