Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMP16Matrix metallopeptidase 16. (607 aa)    
Predicted Functional Partners:
HBEGF
EGF-like domain-containing protein.
   
 0.936
MMP13
Matrix metallopeptidase 13.
   
  0.901
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
     
  0.900
GNAI2
Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1.
     
  0.900
GNAI1
G protein subunit alpha i1.
     
  0.900
TIMP2
NTR domain-containing protein.
   
 0.896
TIMP3
Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity).
   
 0.750
TGFBR3
Transforming growth factor beta receptor 3.
    
 0.689
TGFBR3L
Transforming growth factor beta receptor 3 like.
    
 0.689
TIMP4
TIMP metallopeptidase inhibitor 4.
    
 0.683
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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