STK4 protein (Macaca mulatta) - STRING interaction network

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STK4

Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)

Predicted Functional Partners:

STK3

0.998

RASSF1

0.993

RASSF5

0.992

SAV1

0.984

CASP3

0.967

FOXO1

0.941

FOXO3

0.940

FOXO4

0.940

FOXO6

0.940

RASSF2

0.926

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	FOXO1	ENSMMUP00000070295	ENSMMUP00000036378	Caspase 3; Belongs to the peptidase C14A family.	Forkhead box O1.	0.547
CASP3	FOXO3	ENSMMUP00000070295	ENSMMUP00000032969	Caspase 3; Belongs to the peptidase C14A family.	Forkhead box O3.	0.483
CASP3	SAV1	ENSMMUP00000070295	ENSMMUP00000054043	Caspase 3; Belongs to the peptidase C14A family.	Salvador family WW domain containing protein 1.	0.729
CASP3	STK3	ENSMMUP00000070295	ENSMMUP00000046008	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.968
CASP3	STK4	ENSMMUP00000070295	ENSMMUP00000017358	Caspase 3; Belongs to the peptidase C14A family.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.967
FOXO1	CASP3	ENSMMUP00000036378	ENSMMUP00000070295	Forkhead box O1.	Caspase 3; Belongs to the peptidase C14A family.	0.547
FOXO1	FOXO3	ENSMMUP00000036378	ENSMMUP00000032969	Forkhead box O1.	Forkhead box O3.	0.976
FOXO1	FOXO4	ENSMMUP00000036378	ENSMMUP00000040996	Forkhead box O1.	Fork head domain transcription factor AFX1.	0.703
FOXO1	FOXO6	ENSMMUP00000036378	ENSMMUP00000041442	Forkhead box O1.	Forkhead box O6.	0.732
FOXO1	STK4	ENSMMUP00000036378	ENSMMUP00000017358	Forkhead box O1.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.941
FOXO3	CASP3	ENSMMUP00000032969	ENSMMUP00000070295	Forkhead box O3.	Caspase 3; Belongs to the peptidase C14A family.	0.483
FOXO3	FOXO1	ENSMMUP00000032969	ENSMMUP00000036378	Forkhead box O3.	Forkhead box O1.	0.976
FOXO3	FOXO4	ENSMMUP00000032969	ENSMMUP00000040996	Forkhead box O3.	Fork head domain transcription factor AFX1.	0.717
FOXO3	FOXO6	ENSMMUP00000032969	ENSMMUP00000041442	Forkhead box O3.	Forkhead box O6.	0.644
FOXO3	STK4	ENSMMUP00000032969	ENSMMUP00000017358	Forkhead box O3.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.940
FOXO4	FOXO1	ENSMMUP00000040996	ENSMMUP00000036378	Fork head domain transcription factor AFX1.	Forkhead box O1.	0.703
FOXO4	FOXO3	ENSMMUP00000040996	ENSMMUP00000032969	Fork head domain transcription factor AFX1.	Forkhead box O3.	0.717
FOXO4	FOXO6	ENSMMUP00000040996	ENSMMUP00000041442	Fork head domain transcription factor AFX1.	Forkhead box O6.	0.664
FOXO4	STK4	ENSMMUP00000040996	ENSMMUP00000017358	Fork head domain transcription factor AFX1.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.940
FOXO6	FOXO1	ENSMMUP00000041442	ENSMMUP00000036378	Forkhead box O6.	Forkhead box O1.	0.732

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