STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)    
Predicted Functional Partners:
RASSF1
Ras association domain family member 1.
    
 0.989
RASSF5
Ras association domain family member 5.
   
 0.988
SAV1
Salvador family WW domain containing protein 1.
    
 0.968
STK3
Uncharacterized protein.
  
 
 
0.958
CASP3
Caspase 3; Belongs to the peptidase C14A family.
   
 0.953
MOB1A
Mps one binder kinase activator-like 1B.
   
 0.922
F6SLK3_MACMU
Uncharacterized protein.
   
 0.921
FOXO1
Forkhead box O1.
   
 0.920
FOXO3
Forkhead box O3.
   
 0.919
FOXO4
Fork head domain transcription factor AFX1.
    
 0.917
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (14%) [HD]