LRRK1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BAG5	ENSMMUP00000053665	ENSMMUP00000022372	Tyrosine-protein kinase.	BCL2 associated athanogene 5.	0.505
ABL1	EGFR	ENSMMUP00000053665	ENSMMUP00000046120	Tyrosine-protein kinase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.788
ABL1	GRB2	ENSMMUP00000053665	ENSMMUP00000045339	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.991
ABL1	LRRK1	ENSMMUP00000053665	ENSMMUP00000017517	Tyrosine-protein kinase.	Leucine rich repeat kinase 1.	0.713
ABL1	SHC1	ENSMMUP00000053665	ENSMMUP00000008658	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform 3.	0.991
ABL1	YWHAB	ENSMMUP00000053665	ENSMMUP00000061718	Tyrosine-protein kinase.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.757
BAG1	BAG5	ENSMMUP00000063374	ENSMMUP00000022372	BCL2 associated athanogene 1.	BCL2 associated athanogene 5.	0.705
BAG1	LRRK1	ENSMMUP00000063374	ENSMMUP00000017517	BCL2 associated athanogene 1.	Leucine rich repeat kinase 1.	0.572
BAG5	ABL1	ENSMMUP00000022372	ENSMMUP00000053665	BCL2 associated athanogene 5.	Tyrosine-protein kinase.	0.505
BAG5	BAG1	ENSMMUP00000022372	ENSMMUP00000063374	BCL2 associated athanogene 5.	BCL2 associated athanogene 1.	0.705
BAG5	LRRK1	ENSMMUP00000022372	ENSMMUP00000017517	BCL2 associated athanogene 5.	Leucine rich repeat kinase 1.	0.716
BAG5	LRRK2	ENSMMUP00000022372	ENSMMUP00000020845	BCL2 associated athanogene 5.	Leucine rich repeat kinase 2.	0.772
EGFR	ABL1	ENSMMUP00000046120	ENSMMUP00000053665	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.788
EGFR	GRB2	ENSMMUP00000046120	ENSMMUP00000045339	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Growth factor receptor-bound protein 2 isoform 1.	0.999
EGFR	LRRK1	ENSMMUP00000046120	ENSMMUP00000017517	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Leucine rich repeat kinase 1.	0.587
EGFR	LRRK2	ENSMMUP00000046120	ENSMMUP00000020845	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Leucine rich repeat kinase 2.	0.442
EGFR	SHC1	ENSMMUP00000046120	ENSMMUP00000008658	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	SHC-transforming protein 1 isoform 3.	0.995
EGFR	YWHAB	ENSMMUP00000046120	ENSMMUP00000061718	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.718
GRB2	ABL1	ENSMMUP00000045339	ENSMMUP00000053665	Growth factor receptor-bound protein 2 isoform 1.	Tyrosine-protein kinase.	0.991
GRB2	EGFR	ENSMMUP00000045339	ENSMMUP00000046120	Growth factor receptor-bound protein 2 isoform 1.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.999