IL22RA2 protein (Macaca mulatta) - STRING interaction network

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Score

IL22RA2

Interleukin 22 receptor subunit alpha 2. (251 aa)

Predicted Functional Partners:

IL22

0.979

STAT3

0.913

TYK2

0.862

JAK1

0.858

LOC114669853

0.842

IL10

0.740

IL26

0.693

IL19

0.675

IL24

0.675

IL20

0.650

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL19	ENSMMUP00000031022	ENSMMUP00000031025	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 19.	0.963
IL10	IL20	ENSMMUP00000031022	ENSMMUP00000058829	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 20.	0.922
IL10	IL22	ENSMMUP00000031022	ENSMMUP00000024636	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin-22.	0.991
IL10	IL22RA2	ENSMMUP00000031022	ENSMMUP00000017837	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 2.	0.740
IL10	IL24	ENSMMUP00000031022	ENSMMUP00000031030	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 24.	0.969
IL10	IL26	ENSMMUP00000031022	ENSMMUP00000005837	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 26.	0.941
IL10	JAK1	ENSMMUP00000031022	ENSMMUP00000024423	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.933
IL10	LOC114669853	ENSMMUP00000031022	ENSMMUP00000062520	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.807
IL10	STAT3	ENSMMUP00000031022	ENSMMUP00000043986	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Signal transducer and activator of transcription.	0.974
IL10	TYK2	ENSMMUP00000031022	ENSMMUP00000067206	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.934
IL19	IL10	ENSMMUP00000031025	ENSMMUP00000031022	Interleukin 19.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.963
IL19	IL20	ENSMMUP00000031025	ENSMMUP00000058829	Interleukin 19.	Interleukin 20.	0.913
IL19	IL22	ENSMMUP00000031025	ENSMMUP00000024636	Interleukin 19.	Interleukin-22.	0.967
IL19	IL22RA2	ENSMMUP00000031025	ENSMMUP00000017837	Interleukin 19.	Interleukin 22 receptor subunit alpha 2.	0.675
IL19	IL24	ENSMMUP00000031025	ENSMMUP00000031030	Interleukin 19.	Interleukin 24.	0.945
IL19	IL26	ENSMMUP00000031025	ENSMMUP00000005837	Interleukin 19.	Interleukin 26.	0.978
IL19	JAK1	ENSMMUP00000031025	ENSMMUP00000024423	Interleukin 19.	Tyrosine-protein kinase.	0.812
IL19	LOC114669853	ENSMMUP00000031025	ENSMMUP00000062520	Interleukin 19.	Tyrosine-protein kinase.	0.742
IL19	STAT3	ENSMMUP00000031025	ENSMMUP00000043986	Interleukin 19.	Signal transducer and activator of transcription.	0.546
IL19	TYK2	ENSMMUP00000031025	ENSMMUP00000067206	Interleukin 19.	Tyrosine-protein kinase.	0.804