Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
RNF2E3 ubiquitin-protein ligase RING2. (336 aa)    
Predicted Functional Partners:
RING1
E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...]
  
0.999
CBX4
E3 SUMO-protein ligase CBX4.
    
 0.995
CBX7
Chromo domain-containing protein.
    
 0.995
PHC1
Uncharacterized protein.
    
 0.995
CBX8
Chromobox 8.
    
 0.995
CBX2
Chromobox 2.
    
 0.994
PCGF2
Polycomb group RING finger protein 2.
   
0.994
PCGF6
Polycomb group ring finger 6.
   
 0.990
PHC2
Polyhomeotic homolog 2.
    
 0.990
BMI1
RING-type domain-containing protein.
   
0.988
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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