CYP1B1 protein (Macaca mulatta) - STRING interaction network

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CYP1B1

Uncharacterized protein; Belongs to the cytochrome P450 family. (542 aa)

Predicted Functional Partners:

UGT1A1

0.968

IDO1

0.958

COMT

0.958

EPHX1

0.956

UGT2A3

0.951

LOC709234

0.949

LOC709132

0.949

UGT2B7

0.945

GSTA1

0.944

CYP1A1

0.942

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COMT	CYP1A1	ENSMMUP00000066080	ENSMMUP00000029575	Catechol-O-methyltransferase.	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	0.951
COMT	CYP1B1	ENSMMUP00000066080	ENSMMUP00000018330	Catechol-O-methyltransferase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.958
COMT	LOC709132	ENSMMUP00000066080	ENSMMUP00000021653	Catechol-O-methyltransferase.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.945
COMT	LOC709234	ENSMMUP00000066080	ENSMMUP00000000456	Catechol-O-methyltransferase.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.945
COMT	UGT1A1	ENSMMUP00000066080	ENSMMUP00000027940	Catechol-O-methyltransferase.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.949
COMT	UGT2A3	ENSMMUP00000066080	ENSMMUP00000059551	Catechol-O-methyltransferase.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.945
COMT	UGT2B7	ENSMMUP00000066080	ENSMMUP00000060516	Catechol-O-methyltransferase.	UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.	0.934
CYP1A1	COMT	ENSMMUP00000029575	ENSMMUP00000066080	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Catechol-O-methyltransferase.	0.951
CYP1A1	CYP1B1	ENSMMUP00000029575	ENSMMUP00000018330	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.942
CYP1A1	EPHX1	ENSMMUP00000029575	ENSMMUP00000075589	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.955
CYP1A1	GSTA1	ENSMMUP00000029575	ENSMMUP00000065008	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Uncharacterized protein; Belongs to the GST superfamily.	0.937
CYP1A1	IDO1	ENSMMUP00000029575	ENSMMUP00000032133	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Indoleamine 2,3-dioxygenase 1.	0.930
CYP1A1	LOC709132	ENSMMUP00000029575	ENSMMUP00000021653	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.951
CYP1A1	LOC709234	ENSMMUP00000029575	ENSMMUP00000000456	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.951
CYP1A1	UGT1A1	ENSMMUP00000029575	ENSMMUP00000027940	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.968
CYP1A1	UGT2A3	ENSMMUP00000029575	ENSMMUP00000059551	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.954
CYP1A1	UGT2B7	ENSMMUP00000029575	ENSMMUP00000060516	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.	0.952
CYP1B1	COMT	ENSMMUP00000018330	ENSMMUP00000066080	Uncharacterized protein; Belongs to the cytochrome P450 family.	Catechol-O-methyltransferase.	0.958
CYP1B1	CYP1A1	ENSMMUP00000018330	ENSMMUP00000029575	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	0.942
CYP1B1	EPHX1	ENSMMUP00000018330	ENSMMUP00000075589	Uncharacterized protein; Belongs to the cytochrome P450 family.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.956