Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1632 aa)    
Predicted Functional Partners:
STAM2
Signal transducing adaptor molecule 2.
   
 0.858
DHX30
DExH-box helicase 30.
    
 0.840
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]
   
 0.828
UBAP1
Uncharacterized protein.
    
 0.828
UQCRC1
Ubiquinol-cytochrome c reductase core protein 1.
   
  
 0.816
CHMP4A-2
Uncharacterized protein.
    
 0.804
VPS4B
Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family.
   
 0.792
MIEN1
Migration and invasion enhancer 1.
   
 0.786
CEP19
Centrosomal protein of 19 kDa.
    
 
 0.779
LARS2
Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
  
 0.779
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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