Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)    
Predicted Functional Partners:
NFKB2
Nuclear factor kappa B subunit 2.
   
0.999
RELA
RELA proto-oncogene, NF-kB subunit.
  
 
0.999
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
    
 0.992
NFKBIA
NF-kappa-B inhibitor alpha.
   
 0.988
NFKBIE
NFKB inhibitor epsilon.
   
 0.983
NFKB1
Uncharacterized protein.
   
 0.981
REL
REL proto-oncogene, NF-kB subunit.
    
 
0.963
NFKBIB
NF-kappa-B inhibitor beta isoform a.
   
 0.929
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.
    
 0.876
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 
 0.827
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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