Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
NECTIN2Poliovirus receptor-related protein 2 isoform delta. (538 aa)    
Predicted Functional Partners:
NECTIN3
Nectin cell adhesion molecule 3.
   
0.999
CD226
CD226 antigen; Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
    
 0.999
TIGIT
T cell immunoreceptor with Ig and ITIM domains.
    
 0.993
AFDN
Afadin, adherens junction formation factor.
    
 0.992
NECTIN1
Poliovirus receptor-related protein 1 isoform 1.
   
0.961
CRTAM
Cytotoxic and regulatory T cell molecule.
     
 0.928
NECTIN4
Nectin cell adhesion molecule 4.
     
 
0.918
PARD3
Partitioning defective 3 homolog isoform 2.
   
 
  0.901
PVRIG
PVR related immunoglobulin domain containing.
    
 
 0.839
ZNF395
C2H2-type domain-containing protein.
    
 0.747
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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