node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA1 | APOA1 | ENSMMUP00000061741 | ENSMMUP00000021209 | ATP binding cassette subfamily A member 1. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.998 |
ABCA1 | APOA2 | ENSMMUP00000061741 | ENSMMUP00000006019 | ATP binding cassette subfamily A member 1. | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | 0.831 |
ABCA1 | APOB | ENSMMUP00000061741 | ENSMMUP00000010112 | ATP binding cassette subfamily A member 1. | Apolipoprotein B. | 0.859 |
ABCA1 | APOC3 | ENSMMUP00000061741 | ENSMMUP00000074005 | ATP binding cassette subfamily A member 1. | Uncharacterized protein. | 0.674 |
ABCA1 | APOE | ENSMMUP00000061741 | ENSMMUP00000048554 | ATP binding cassette subfamily A member 1. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.934 |
APOA1 | ABCA1 | ENSMMUP00000021209 | ENSMMUP00000061741 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | ATP binding cassette subfamily A member 1. | 0.998 |
APOA1 | APOA2 | ENSMMUP00000021209 | ENSMMUP00000006019 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | 0.997 |
APOA1 | APOB | ENSMMUP00000021209 | ENSMMUP00000010112 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Apolipoprotein B. | 0.997 |
APOA1 | APOC1 | ENSMMUP00000021209 | ENSMMUP00000031571 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Cholesteryl ester transfer inhibitor protein; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. [...] | 0.906 |
APOA1 | APOC2 | ENSMMUP00000021209 | ENSMMUP00000078807 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Uncharacterized protein. | 0.957 |
APOA1 | APOC3 | ENSMMUP00000021209 | ENSMMUP00000074005 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Uncharacterized protein. | 0.979 |
APOA1 | APOE | ENSMMUP00000021209 | ENSMMUP00000048554 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.993 |
APOA1 | APP | ENSMMUP00000021209 | ENSMMUP00000018894 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | 0.686 |
APOA1 | LRP2 | ENSMMUP00000021209 | ENSMMUP00000077987 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | LDL receptor related protein 2. | 0.470 |
APOA2 | ABCA1 | ENSMMUP00000006019 | ENSMMUP00000061741 | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | ATP binding cassette subfamily A member 1. | 0.831 |
APOA2 | APOA1 | ENSMMUP00000006019 | ENSMMUP00000021209 | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.997 |
APOA2 | APOB | ENSMMUP00000006019 | ENSMMUP00000010112 | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | Apolipoprotein B. | 0.990 |
APOA2 | APOC1 | ENSMMUP00000006019 | ENSMMUP00000031571 | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | Cholesteryl ester transfer inhibitor protein; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. [...] | 0.919 |
APOA2 | APOC2 | ENSMMUP00000006019 | ENSMMUP00000078807 | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | Uncharacterized protein. | 0.948 |
APOA2 | APOC3 | ENSMMUP00000006019 | ENSMMUP00000074005 | Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. | Uncharacterized protein. | 0.986 |