STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PGRMC1Membrane-associated progesterone receptor component 1; Belongs to the cytochrome b5 family. (195 aa)    
Predicted Functional Partners:
PGR
Uncharacterized protein.
      
 0.839
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
    
 
 0.800
SERBP1
HABP4_PAI-RBP1 domain-containing protein.
      
 0.772
OXTR
Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
      
 0.715
PAQR7
Progestin and adipoQ receptor family member 7.
    
 
 0.669
TMEM97
Transmembrane protein 97.
      
 0.651
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
    
 
 0.630
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
      
 0.624
EGFR
Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]
      
 0.592
CYB5A
Uncharacterized protein; Belongs to the cytochrome b5 family.
   
  
 0.530
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.