STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JAK2Tyrosine-protein kinase. (1137 aa)    
Predicted Functional Partners:
STAT3
Signal transducer and activator of transcription.
   
 0.999
STAT1
Signal transducer and activator of transcription.
   
 0.998
SOCS3
Suppressor of cytokine signaling 3.
   
 0.998
EPOR
Erythropoietin receptor; Receptor for erythropoietin.
    
 0.997
SOCS1
Suppressor of cytokine signaling 1.
   
 0.997
STAT5A
Signal transducer and activator of transcription.
   
 0.997
IFNGR2
Interferon gamma receptor 2.
   
 0.997
LEPR
Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...]
    
 0.996
STAT5B
Signal transducer and activator of transcription.
   
 0.996
STAT6
Signal transducer and activator of transcription.
   
 0.994
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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