ICAM2 protein (Macaca mulatta) - STRING interaction network

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Score

ICAM2

ICAM_N domain-containing protein. (275 aa)

Predicted Functional Partners:

ITGB2

0.963

ITGAL

0.958

ITGAM

0.943

ICAM1

0.924

CD209

0.865

RDX

0.833

CLEC4A

0.795

CLEC6A

0.775

TLR4

0.754

CLEC4D

0.753

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD209	ICAM1	ENSMMUP00000029559	ENSMMUP00000012236	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	0.498
CD209	ICAM2	ENSMMUP00000029559	ENSMMUP00000019231	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	ICAM_N domain-containing protein.	0.865
CD209	TLR4	ENSMMUP00000029559	ENSMMUP00000039787	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.678
CLEC4A	ICAM2	ENSMMUP00000070257	ENSMMUP00000019231	C-type lectin domain family 4 member A.	ICAM_N domain-containing protein.	0.795
CLEC4D	ICAM2	ENSMMUP00000018021	ENSMMUP00000019231	C-type lectin domain family 4 member D.	ICAM_N domain-containing protein.	0.753
CLEC6A	ICAM2	ENSMMUP00000018015	ENSMMUP00000019231	C-type lectin domain containing 6A.	ICAM_N domain-containing protein.	0.775
CLEC6A	TLR4	ENSMMUP00000018015	ENSMMUP00000039787	C-type lectin domain containing 6A.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.422
ICAM1	CD209	ENSMMUP00000012236	ENSMMUP00000029559	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	0.498
ICAM1	ICAM2	ENSMMUP00000012236	ENSMMUP00000019231	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	ICAM_N domain-containing protein.	0.924
ICAM1	ITGAL	ENSMMUP00000012236	ENSMMUP00000032459	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	Integrin subunit alpha L; Belongs to the integrin alpha chain family.	0.997
ICAM1	ITGAM	ENSMMUP00000012236	ENSMMUP00000052151	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.990
ICAM1	ITGB2	ENSMMUP00000012236	ENSMMUP00000073991	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	Integrin beta.	0.995
ICAM1	RDX	ENSMMUP00000012236	ENSMMUP00000002993	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	Radixin.	0.463
ICAM1	TLR4	ENSMMUP00000012236	ENSMMUP00000039787	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.722
ICAM2	CD209	ENSMMUP00000019231	ENSMMUP00000029559	ICAM_N domain-containing protein.	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	0.865
ICAM2	CLEC4A	ENSMMUP00000019231	ENSMMUP00000070257	ICAM_N domain-containing protein.	C-type lectin domain family 4 member A.	0.795
ICAM2	CLEC4D	ENSMMUP00000019231	ENSMMUP00000018021	ICAM_N domain-containing protein.	C-type lectin domain family 4 member D.	0.753
ICAM2	CLEC6A	ENSMMUP00000019231	ENSMMUP00000018015	ICAM_N domain-containing protein.	C-type lectin domain containing 6A.	0.775
ICAM2	ICAM1	ENSMMUP00000019231	ENSMMUP00000012236	ICAM_N domain-containing protein.	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.	0.924
ICAM2	ITGAL	ENSMMUP00000019231	ENSMMUP00000032459	ICAM_N domain-containing protein.	Integrin subunit alpha L; Belongs to the integrin alpha chain family.	0.958