Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LYNX1-SLURP2Secreted Ly-6/uPAR domain-containing protein 2; Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs, strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7- containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha- 3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CH [...] (131 aa)    
Predicted Functional Partners:
SLURP1
Secreted LY6/PLAUR domain containing 1.
   
 
 0.950
LYPD6B
LY6/PLAUR domain containing 6B.
     
 0.908
LYPD6
Ly6/PLAUR domain-containing protein 6.
     
 0.905
PATE1
Prostate and testis expressed 1.
     
  0.900
PATE2
Uncharacterized protein.
     
  0.900
PATE4
Uncharacterized protein.
     
  0.900
PATE3
Uncharacterized protein.
     
  0.900
LOC574167
Sc328.
     
  0.900
CHRNA9
Cholinergic receptor nicotinic alpha 9 subunit.
     
 0.726
CHRNA10
Cholinergic receptor nicotinic alpha 10 subunit.
   
 
 0.692
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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