TAB2 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TAB2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)

Predicted Functional Partners:

TAB1

0.999

TRAF6

0.999

MAP3K7

0.999

IRAK1

0.997

IKBKG

0.997

TAB3

0.997

RIPK1

0.996

TRAF2

0.990

IKBKB

0.977

CHUK

0.977

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	IKBKB	ENSMMUP00000043850	ENSMMUP00000032125	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	0.999
CHUK	IKBKG	ENSMMUP00000043850	ENSMMUP00000040739	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.999
CHUK	IRAK1	ENSMMUP00000043850	ENSMMUP00000024614	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin 1 receptor associated kinase 1.	0.981
CHUK	MAP3K7	ENSMMUP00000043850	ENSMMUP00000033340	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7.	0.996
CHUK	RIPK1	ENSMMUP00000043850	ENSMMUP00000011125	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor interacting serine/threonine kinase 1.	0.995
CHUK	TAB1	ENSMMUP00000043850	ENSMMUP00000015873	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha.	0.973
CHUK	TAB2	ENSMMUP00000043850	ENSMMUP00000019658	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.977
CHUK	TAB3	ENSMMUP00000043850	ENSMMUP00000058072	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3.	0.980
CHUK	TRAF2	ENSMMUP00000043850	ENSMMUP00000015133	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.996
CHUK	TRAF6	ENSMMUP00000043850	ENSMMUP00000024012	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.998
IKBKB	CHUK	ENSMMUP00000032125	ENSMMUP00000043850	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.999
IKBKB	IKBKG	ENSMMUP00000032125	ENSMMUP00000040739	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.999
IKBKB	IRAK1	ENSMMUP00000032125	ENSMMUP00000024614	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	Interleukin 1 receptor associated kinase 1.	0.744
IKBKB	MAP3K7	ENSMMUP00000032125	ENSMMUP00000033340	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	Mitogen-activated protein kinase kinase kinase 7.	0.996
IKBKB	RIPK1	ENSMMUP00000032125	ENSMMUP00000011125	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	Receptor interacting serine/threonine kinase 1.	0.995
IKBKB	TAB1	ENSMMUP00000032125	ENSMMUP00000015873	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha.	0.979
IKBKB	TAB2	ENSMMUP00000032125	ENSMMUP00000019658	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.977
IKBKB	TAB3	ENSMMUP00000032125	ENSMMUP00000058072	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3.	0.976
IKBKB	TRAF2	ENSMMUP00000032125	ENSMMUP00000015133	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.996
IKBKB	TRAF6	ENSMMUP00000032125	ENSMMUP00000024012	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.998