Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (338 aa)    
Predicted Functional Partners:
IL2
Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.
    
 0.999
IL2RB
Interleukin 2 receptor subunit beta.
   
 0.998
STAT5A
Signal transducer and activator of transcription.
   
 0.990
STAT5B
Signal transducer and activator of transcription.
   
 0.984
IL2RG
Cytokine receptor common subunit gamma.
   
 0.984
JAK1
Tyrosine-protein kinase.
   
 
 0.984
IL7R
Interleukin 7 receptor.
     
 0.969
LOC114669853
Tyrosine-protein kinase.
   
 
 0.956
FOXP3
Forkhead box P3.
   
 0.955
IL21R
Interleukin 21 receptor.
   
 
 0.952
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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