Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DPH22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa)    
Predicted Functional Partners:
DPH3
DPH3 homolog isoform 1.
   
 0.996
DPH1
Diphthamide biosynthesis 1.
   
0.989
DPH5
Diphthine synthase isoform a.
   
 0.980
EEF2
Elongation factor 2.
    
 0.970
DPH7
Diphthamide biosynthesis 7.
      
 0.881
DPH6
Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
      
 0.815
RRP9
Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein.
   
    0.719
DDX31
RNA helicase.
   
   0.718
DDX56
DEAD-box helicase 56.
   
 
 0.664
GCSH
Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.
      
 0.661
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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