Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
C11H12orf4Chromosome 11 C12orf4 homolog. (577 aa)    
Predicted Functional Partners:
PPP1R21
Protein phosphatase 1 regulatory subunit 21.
    
 
 0.906
TBCK
TBC1 domain containing kinase.
    
 
 0.883
CRYZL1
Crystallin zeta like 1.
    
   0.741
IL6R
Interleukin 6 receptor.
    
   0.732
SLX1A
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
   
    0.601
EXOC8
Exocyst complex component 8.
   
    0.599
TBC1D31
Uncharacterized protein.
    
 
 0.583
GIMD1
GIMAP family P-loop NTPase domain containing 1.
    
 
 0.583
C18H18orf63
Chromosome 18 C18orf63 homolog.
      
 0.527
TCP10
Tcp10_C domain-containing protein.
   
 
 0.496
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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