GRB14 protein (Macaca mulatta) - STRING interaction network

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[Homology]

Score

GRB14

Growth factor receptor bound protein 14. (540 aa)

Predicted Functional Partners:

INSR

0.907

IGF1R

0.824

INSIG1

0.747

TEK

0.743

CARD9

0.739

RET

0.717

ITGB6

0.716

FGFR1

0.705

PERP

0.705

LY75

0.691

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD9	GRB14	ENSMMUP00000004116	ENSMMUP00000020055	Caspase recruitment domain family member 9.	Growth factor receptor bound protein 14.	0.739
FGFR1	GRB14	ENSMMUP00000029571	ENSMMUP00000020055	Fibroblast growth factor receptor.	Growth factor receptor bound protein 14.	0.705
GRB14	CARD9	ENSMMUP00000020055	ENSMMUP00000004116	Growth factor receptor bound protein 14.	Caspase recruitment domain family member 9.	0.739
GRB14	FGFR1	ENSMMUP00000020055	ENSMMUP00000029571	Growth factor receptor bound protein 14.	Fibroblast growth factor receptor.	0.705
GRB14	IGF1R	ENSMMUP00000020055	ENSMMUP00000016141	Growth factor receptor bound protein 14.	Tyrosine-protein kinase receptor.	0.824
GRB14	INSIG1	ENSMMUP00000020055	ENSMMUP00000013766	Growth factor receptor bound protein 14.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.747
GRB14	INSR	ENSMMUP00000020055	ENSMMUP00000045695	Growth factor receptor bound protein 14.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.907
GRB14	ITGB6	ENSMMUP00000020055	ENSMMUP00000053563	Growth factor receptor bound protein 14.	Integrin beta; Belongs to the integrin beta chain family.	0.716
GRB14	LY75	ENSMMUP00000020055	ENSMMUP00000056295	Growth factor receptor bound protein 14.	Uncharacterized protein.	0.691
GRB14	PERP	ENSMMUP00000020055	ENSMMUP00000064183	Growth factor receptor bound protein 14.	P53 apoptosis effector related to PMP22.	0.705
GRB14	RET	ENSMMUP00000020055	ENSMMUP00000020196	Growth factor receptor bound protein 14.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.717
GRB14	TEK	ENSMMUP00000020055	ENSMMUP00000007986	Growth factor receptor bound protein 14.	TEK receptor tyrosine kinase.	0.743
IGF1R	GRB14	ENSMMUP00000016141	ENSMMUP00000020055	Tyrosine-protein kinase receptor.	Growth factor receptor bound protein 14.	0.824
IGF1R	INSIG1	ENSMMUP00000016141	ENSMMUP00000013766	Tyrosine-protein kinase receptor.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.462
IGF1R	INSR	ENSMMUP00000016141	ENSMMUP00000045695	Tyrosine-protein kinase receptor.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.994
INSIG1	GRB14	ENSMMUP00000013766	ENSMMUP00000020055	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Growth factor receptor bound protein 14.	0.747
INSIG1	IGF1R	ENSMMUP00000013766	ENSMMUP00000016141	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Tyrosine-protein kinase receptor.	0.462
INSIG1	PERP	ENSMMUP00000013766	ENSMMUP00000064183	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	P53 apoptosis effector related to PMP22.	0.642
INSR	GRB14	ENSMMUP00000045695	ENSMMUP00000020055	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	Growth factor receptor bound protein 14.	0.907
INSR	IGF1R	ENSMMUP00000045695	ENSMMUP00000016141	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	Tyrosine-protein kinase receptor.	0.994