node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCR7 | CD38 | ENSMMUP00000002799 | ENSMMUP00000020061 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | ADP-ribosyl cyclase 1. | 0.833 |
CCR7 | CD4 | ENSMMUP00000002799 | ENSMMUP00000069370 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.936 |
CCR7 | CD69 | ENSMMUP00000002799 | ENSMMUP00000020060 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | CD69 molecule. | 0.863 |
CCR7 | FCGR3 | ENSMMUP00000002799 | ENSMMUP00000049334 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). | 0.798 |
CCR7 | GZMB | ENSMMUP00000002799 | ENSMMUP00000018888 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Granzyme B; Belongs to the peptidase S1 family. | 0.803 |
CCR7 | IFNG | ENSMMUP00000002799 | ENSMMUP00000065064 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.855 |
CCR7 | IL2 | ENSMMUP00000002799 | ENSMMUP00000027764 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.827 |
CCR7 | S1PR1 | ENSMMUP00000002799 | ENSMMUP00000048029 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.647 |
CCR7 | SELL | ENSMMUP00000002799 | ENSMMUP00000053784 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. | 0.920 |
CCR7 | TNF | ENSMMUP00000002799 | ENSMMUP00000056761 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.811 |
CD38 | CCR7 | ENSMMUP00000020061 | ENSMMUP00000002799 | ADP-ribosyl cyclase 1. | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.833 |
CD38 | CD4 | ENSMMUP00000020061 | ENSMMUP00000069370 | ADP-ribosyl cyclase 1. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.915 |
CD38 | CD69 | ENSMMUP00000020061 | ENSMMUP00000020060 | ADP-ribosyl cyclase 1. | CD69 molecule. | 0.857 |
CD38 | FCGR3 | ENSMMUP00000020061 | ENSMMUP00000049334 | ADP-ribosyl cyclase 1. | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). | 0.861 |
CD38 | GZMB | ENSMMUP00000020061 | ENSMMUP00000018888 | ADP-ribosyl cyclase 1. | Granzyme B; Belongs to the peptidase S1 family. | 0.724 |
CD38 | IFNG | ENSMMUP00000020061 | ENSMMUP00000065064 | ADP-ribosyl cyclase 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.802 |
CD38 | IL2 | ENSMMUP00000020061 | ENSMMUP00000027764 | ADP-ribosyl cyclase 1. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.780 |
CD38 | SELL | ENSMMUP00000020061 | ENSMMUP00000053784 | ADP-ribosyl cyclase 1. | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. | 0.643 |
CD38 | TNF | ENSMMUP00000020061 | ENSMMUP00000056761 | ADP-ribosyl cyclase 1. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.706 |
CD4 | CCR7 | ENSMMUP00000069370 | ENSMMUP00000002799 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.936 |