Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ABCA7ATP binding cassette subfamily A member 7. (2111 aa)    
Predicted Functional Partners:
PICALM
Phosphatidylinositol binding clathrin assembly protein.
      
 0.836
APOA1
Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.
    
 0.834
SORL1
Sortilin related receptor 1.
    
 
 0.800
CD2AP
CD2-associated protein.
      
 0.778
EPHA1
EPH receptor A1.
   
  
 0.778
BIN1
Bridging integrator 1.
   
  
 0.776
CD33
CD33 molecule.
   
  
 0.771
CLU
Clusterin; Belongs to the clusterin family.
    
 
 0.758
TREM2
Triggering receptor expressed on myeloid cells 2.
   
  
 0.725
MS4A6A
Membrane spanning 4-domains A6A.
      
 0.672
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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