Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HELQHelicase, POLQ like. (1101 aa)    
Predicted Functional Partners:
FANCD2
Uncharacterized protein.
   
 0.904
POLN
DNA polymerase nu.
 
  
 
 0.792
EXO1
Exonuclease 1.
  
 
 0.758
MCM9
Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.
   
  
 0.753
FANCL
FA complementation group L.
     
 0.745
FANCM
FA complementation group M.
   
 
 0.727
RAD51B
RAD51 paralog B.
  
 
 0.706
FANCI
FA complementation group I.
   
 0.696
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit.
     
 0.669
FANCC
Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
     
 0.665
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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