| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARAF | BRAF | ENSMMUP00000074132 | ENSMMUP00000044832 | A-Raf proto-oncogene, serine/threonine kinase. | B-Raf proto-oncogene, serine/threonine kinase. | 0.999 |
| ARAF | EGFR | ENSMMUP00000074132 | ENSMMUP00000046120 | A-Raf proto-oncogene, serine/threonine kinase. | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | 0.682 |
| ARAF | HRAS | ENSMMUP00000074132 | ENSMMUP00000028522 | A-Raf proto-oncogene, serine/threonine kinase. | Transforming protein p21. | 0.987 |
| ARAF | KRAS | ENSMMUP00000074132 | ENSMMUP00000002635 | A-Raf proto-oncogene, serine/threonine kinase. | KRAS proto-oncogene, GTPase. | 0.897 |
| ARAF | NRAS | ENSMMUP00000074132 | ENSMMUP00000050401 | A-Raf proto-oncogene, serine/threonine kinase. | NRAS proto-oncogene, GTPase. | 0.990 |
| ARAF | RAF1 | ENSMMUP00000074132 | ENSMMUP00000057089 | A-Raf proto-oncogene, serine/threonine kinase. | Uncharacterized protein. | 0.997 |
| ARAF | SOS1 | ENSMMUP00000074132 | ENSMMUP00000066881 | A-Raf proto-oncogene, serine/threonine kinase. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.570 |
| BRAF | ARAF | ENSMMUP00000044832 | ENSMMUP00000074132 | B-Raf proto-oncogene, serine/threonine kinase. | A-Raf proto-oncogene, serine/threonine kinase. | 0.999 |
| BRAF | EGFR | ENSMMUP00000044832 | ENSMMUP00000046120 | B-Raf proto-oncogene, serine/threonine kinase. | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | 0.598 |
| BRAF | HRAS | ENSMMUP00000044832 | ENSMMUP00000028522 | B-Raf proto-oncogene, serine/threonine kinase. | Transforming protein p21. | 0.998 |
| BRAF | KRAS | ENSMMUP00000044832 | ENSMMUP00000002635 | B-Raf proto-oncogene, serine/threonine kinase. | KRAS proto-oncogene, GTPase. | 0.994 |
| BRAF | NF1 | ENSMMUP00000044832 | ENSMMUP00000008965 | B-Raf proto-oncogene, serine/threonine kinase. | Neurofibromin 1. | 0.764 |
| BRAF | NRAS | ENSMMUP00000044832 | ENSMMUP00000050401 | B-Raf proto-oncogene, serine/threonine kinase. | NRAS proto-oncogene, GTPase. | 0.999 |
| BRAF | PIK3CA | ENSMMUP00000044832 | ENSMMUP00000006866 | B-Raf proto-oncogene, serine/threonine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.830 |
| BRAF | RAF1 | ENSMMUP00000044832 | ENSMMUP00000057089 | B-Raf proto-oncogene, serine/threonine kinase. | Uncharacterized protein. | 0.999 |
| BRAF | SOS1 | ENSMMUP00000044832 | ENSMMUP00000066881 | B-Raf proto-oncogene, serine/threonine kinase. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.714 |
| BRAF | TP53 | ENSMMUP00000044832 | ENSMMUP00000011334 | B-Raf proto-oncogene, serine/threonine kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.822 |
| EGFR | ARAF | ENSMMUP00000046120 | ENSMMUP00000074132 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | A-Raf proto-oncogene, serine/threonine kinase. | 0.682 |
| EGFR | BRAF | ENSMMUP00000046120 | ENSMMUP00000044832 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | B-Raf proto-oncogene, serine/threonine kinase. | 0.598 |
| EGFR | HRAS | ENSMMUP00000046120 | ENSMMUP00000028522 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Transforming protein p21. | 0.982 |
