Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)    
Predicted Functional Partners:
GFRA1
GDNF family receptor alpha 1.
    
 0.995
GDNF
Glial cell derived neurotrophic factor.
    
 0.992
GFRA2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    
 0.988
NRTN
Neurturin preproprotein.
    
 0.985
NRAS
NRAS proto-oncogene, GTPase.
    
 0.969
HRAS
Transforming protein p21.
    
 0.968
CCDC6
Coiled-coil domain containing 6.
     
 0.964
GFRA3
GDNF family receptor alpha 3.
    
 0.960
GFRA4
GDNF family receptor alpha 4.
     
 0.959
NCOA4
Nuclear receptor coactivator 4.
     
 0.959
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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