Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LRRC52Leucine rich repeat containing 52. (313 aa)    
Predicted Functional Partners:
KCNMA1
Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...]
     
 0.733
MGST3
Uncharacterized protein.
 
    
 0.717
POGK
Pogo transposable element with KRAB domain.
      
 0.666
CATSPER1
Cation channel sperm associated 1.
     
 0.661
KCNMB4
Potassium calcium-activated channel subfamily M regulatory beta subunit 4.
      
 0.660
UCK2
Uridine-cytidine kinase; Belongs to the uridine kinase family.
    
 0.654
KCNU1
Potassium calcium-activated channel subfamily U member 1.
     
 0.623
KCNMB1
Calcium-activated potassium channel subunit beta-1.
     
 0.601
TMCO1
Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family.
      
 0.581
LRRC26
Leucine rich repeat containing 26.
      
 0.579
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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