Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)    
Predicted Functional Partners:
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit.
   
 0.999
SLX4
SLX4 structure-specific endonuclease subunit.
   
 0.992
XPA
XPA, DNA damage recognition and repair factor.
    
 0.988
MUS81
MUS81 structure-specific endonuclease subunit.
    
 0.979
ERCC3
TFIIH basal transcription factor complex helicase XPB subunit.
   
 0.976
ERCC2
TFIIH basal transcription factor complex helicase XPD subunit isoform 1.
   
 0.950
SLX1A
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
   
 0.945
BIVM
BIVM-ERCC5 readthrough.
   
 0.935
FANCD2
Uncharacterized protein.
   
 0.927
RAD51
RAD51 recombinase; Belongs to the RecA family.
   
 0.924
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.