Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NPM1Nucleophosmin isoform 1. (294 aa)    
Predicted Functional Partners:
NCL
Nucleolin.
   
 
 0.893
LOC712274
40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.
   
 
 0.817
MED22
SURF6 domain-containing protein.
   
 
 0.809
RPL4
60S ribosomal protein L4.
   
 
 0.786
ENSMMUP00000064994
Uncharacterized protein.
   
 
 0.786
RPL15
Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.
   
   0.771
LOC703455
40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3.
   
   0.761
RPL8
60S ribosomal protein L8.
   
   0.759
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.755
RPL5
60S ribosomal protein L5.
   
 
 0.744
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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