Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PPARDPeroxisome proliferator-activated receptor delta isoform 1. (441 aa)    
Predicted Functional Partners:
RXRA
Retinoid X receptor alpha.
    
0.991
RXRG
Retinoid X receptor gamma.
    
0.984
RXRB
Retinoid X receptor beta.
    
0.960
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
  
 
0.931
PLA2G15
Group XV phospholipase A2.
     
 0.907
LIPA
Lipase; Belongs to the AB hydrolase superfamily. Lipase family.
    
 0.905
NCOR1
Nuclear receptor corepressor 1.
    
 0.883
PPARGC1A
PPARG coactivator 1 alpha.
    
 0.876
NCOR2
Nuclear receptor corepressor 2.
    
 0.817
NCOA1
Nuclear receptor coactivator.
    
 0.807
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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