Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CHRNA4Uncharacterized protein. (625 aa)    
Predicted Functional Partners:
CHRNB2
Neuronal acetylcholine receptor subunit beta-2.
  
0.993
CHRNA5
Cholinergic receptor nicotinic alpha 5 subunit.
  
0.986
CHRNB3
Neuronal acetylcholine receptor subunit beta-3.
  
0.986
CHRNB4
Cholinergic receptor nicotinic beta 4 subunit.
  
0.983
CHRNA6
Cholinergic receptor nicotinic alpha 6 subunit.
  
0.983
CHRNB1
Cholinergic receptor nicotinic beta 1 subunit.
  
0.960
CHRNG
Cholinergic receptor nicotinic gamma subunit.
  
0.960
CHRNA7
Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).
  
0.959
CHRNA3
Cholinergic receptor nicotinic alpha 3 subunit.
  
0.958
CHRND
Cholinergic receptor nicotinic delta subunit.
   
0.958
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (32%) [HD]