Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
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[Homology]
Score
KCNQ2Potassium voltage-gated channel subfamily Q member 2. (1110 aa)    
Predicted Functional Partners:
KCNQ3
Potassium voltage-gated channel subfamily KQT member 3 isoform 1; Belongs to the potassium channel family.
  
0.989
KCNQ1
Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.
  
 
0.959
KCNQ5
Potassium voltage-gated channel subfamily Q member 5.
  
  
0.948
KCNQ4
Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.
  
  
0.926
KCNJ4
Potassium voltage-gated channel subfamily J member 4.
   
 
 0.921
KCNJ2
Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...]
   
 
 0.919
KCNJ12
Uncharacterized protein.
   
 
 0.916
KCNJ14
Potassium voltage-gated channel subfamily J member 14.
   
 
 0.910
SCN2A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
   
 0.794
FAU
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
  0.742
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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