STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDN2Endothelin 2. (206 aa)    
Predicted Functional Partners:
EDNRB
Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.
     
 0.988
EDNRA
Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family.
     
 0.985
EDN1
Preproendothelin-1.
     
0.954
EDN3
Endothelin 3.
     
0.953
OXTR
Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
   
 
 0.774
AGTR2
Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.
     
 0.769
AGTR1
Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.
     
 0.722
HTR1E
5-hydroxytryptamine receptor 1E.
   
 
 0.698
HTR1A
5-hydroxytryptamine receptor 1A.
     
 0.698
ADRB2
Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
     
 0.698
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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