| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOX2 | CYP1A1 | ENSMMUP00000007691 | ENSMMUP00000029575 | Uncharacterized protein. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.923 |
| AOX2 | CYP2A23 | ENSMMUP00000007691 | ENSMMUP00000079626 | Uncharacterized protein. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.501 |
| AOX2 | CYP2B6 | ENSMMUP00000007691 | ENSMMUP00000024146 | Uncharacterized protein. | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | 0.932 |
| AOX2 | CYP2D42 | ENSMMUP00000007691 | ENSMMUP00000023613 | Uncharacterized protein. | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. | 0.546 |
| AOX2 | CYP2E1 | ENSMMUP00000007691 | ENSMMUP00000049288 | Uncharacterized protein. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.553 |
| AOX2 | CYP3A4 | ENSMMUP00000007691 | ENSMMUP00000004730 | Uncharacterized protein. | Uncharacterized protein. | 0.955 |
| AOX2 | LOC709132 | ENSMMUP00000007691 | ENSMMUP00000021653 | Uncharacterized protein. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.937 |
| COMT | CYP1A1 | ENSMMUP00000066080 | ENSMMUP00000029575 | Catechol-O-methyltransferase. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.951 |
| COMT | CYP1B1 | ENSMMUP00000066080 | ENSMMUP00000018330 | Catechol-O-methyltransferase. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.958 |
| COMT | CYP2D42 | ENSMMUP00000066080 | ENSMMUP00000023613 | Catechol-O-methyltransferase. | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. | 0.455 |
| COMT | LOC709132 | ENSMMUP00000066080 | ENSMMUP00000021653 | Catechol-O-methyltransferase. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.945 |
| CYP19A1 | CYP1A1 | ENSMMUP00000053305 | ENSMMUP00000029575 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.954 |
| CYP19A1 | CYP1B1 | ENSMMUP00000053305 | ENSMMUP00000018330 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.644 |
| CYP19A1 | CYP2A23 | ENSMMUP00000053305 | ENSMMUP00000079626 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.422 |
| CYP19A1 | CYP2B6 | ENSMMUP00000053305 | ENSMMUP00000024146 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | 0.462 |
| CYP19A1 | CYP2D42 | ENSMMUP00000053305 | ENSMMUP00000023613 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. | 0.450 |
| CYP19A1 | CYP2E1 | ENSMMUP00000053305 | ENSMMUP00000049288 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.426 |
| CYP19A1 | CYP3A4 | ENSMMUP00000053305 | ENSMMUP00000004730 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | Uncharacterized protein. | 0.403 |
| CYP19A1 | LOC709132 | ENSMMUP00000053305 | ENSMMUP00000021653 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.939 |
| CYP1A1 | AOX2 | ENSMMUP00000029575 | ENSMMUP00000007691 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Uncharacterized protein. | 0.923 |
