| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL1 | EP300 | ENSMMUP00000053665 | ENSMMUP00000076664 | Tyrosine-protein kinase. | Histone acetyltransferase p300. | 0.474 |
| ABL1 | MDM2 | ENSMMUP00000053665 | ENSMMUP00000018645 | Tyrosine-protein kinase. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.801 |
| ABL1 | TP53 | ENSMMUP00000053665 | ENSMMUP00000011334 | Tyrosine-protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.852 |
| ABL1 | TP63 | ENSMMUP00000053665 | ENSMMUP00000038274 | Tyrosine-protein kinase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.481 |
| ABL1 | TP73 | ENSMMUP00000053665 | ENSMMUP00000021769 | Tyrosine-protein kinase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.785 |
| ABL1 | WWTR1 | ENSMMUP00000053665 | ENSMMUP00000024971 | Tyrosine-protein kinase. | WW domain containing transcription regulator 1. | 0.649 |
| ABL1 | YAP1 | ENSMMUP00000053665 | ENSMMUP00000004529 | Tyrosine-protein kinase. | Yes associated protein 1. | 0.722 |
| EP300 | ABL1 | ENSMMUP00000076664 | ENSMMUP00000053665 | Histone acetyltransferase p300. | Tyrosine-protein kinase. | 0.474 |
| EP300 | MDM2 | ENSMMUP00000076664 | ENSMMUP00000018645 | Histone acetyltransferase p300. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.956 |
| EP300 | MDM4 | ENSMMUP00000076664 | ENSMMUP00000014729 | Histone acetyltransferase p300. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.487 |
| EP300 | TP53 | ENSMMUP00000076664 | ENSMMUP00000011334 | Histone acetyltransferase p300. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.998 |
| EP300 | TP63 | ENSMMUP00000076664 | ENSMMUP00000038274 | Histone acetyltransferase p300. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.818 |
| EP300 | TP73 | ENSMMUP00000076664 | ENSMMUP00000021769 | Histone acetyltransferase p300. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.930 |
| EP300 | WWTR1 | ENSMMUP00000076664 | ENSMMUP00000024971 | Histone acetyltransferase p300. | WW domain containing transcription regulator 1. | 0.598 |
| EP300 | YAP1 | ENSMMUP00000076664 | ENSMMUP00000004529 | Histone acetyltransferase p300. | Yes associated protein 1. | 0.662 |
| ITCH | MDM2 | ENSMMUP00000016958 | ENSMMUP00000018645 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.597 |
| ITCH | TP53 | ENSMMUP00000016958 | ENSMMUP00000011334 | E3 ubiquitin-protein ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.831 |
| ITCH | TP53BP2 | ENSMMUP00000016958 | ENSMMUP00000014590 | E3 ubiquitin-protein ligase. | Tumor protein p53 binding protein 2. | 0.553 |
| ITCH | TP63 | ENSMMUP00000016958 | ENSMMUP00000038274 | E3 ubiquitin-protein ligase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.959 |
| ITCH | TP73 | ENSMMUP00000016958 | ENSMMUP00000021769 | E3 ubiquitin-protein ligase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.941 |
