node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IKBKG | IRAK1 | ENSMMUP00000040739 | ENSMMUP00000024614 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Interleukin 1 receptor associated kinase 1. | 0.971 |
IKBKG | IRAK4 | ENSMMUP00000040739 | ENSMMUP00000000286 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Interleukin-1 receptor-associated kinase 4. | 0.996 |
IKBKG | MAP3K7 | ENSMMUP00000040739 | ENSMMUP00000033340 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Mitogen-activated protein kinase kinase kinase 7. | 0.997 |
IKBKG | MAVS | ENSMMUP00000040739 | ENSMMUP00000022556 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Mitochondrial antiviral-signaling protein isoform 1. | 0.968 |
IKBKG | MYD88 | ENSMMUP00000040739 | ENSMMUP00000001339 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.960 |
IKBKG | TAB1 | ENSMMUP00000040739 | ENSMMUP00000015873 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. | 0.996 |
IKBKG | TAB2 | ENSMMUP00000040739 | ENSMMUP00000019658 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. | 0.997 |
IKBKG | TRAF5 | ENSMMUP00000040739 | ENSMMUP00000038268 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.959 |
IKBKG | TRAF6 | ENSMMUP00000040739 | ENSMMUP00000024012 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.998 |
IRAK1 | IKBKG | ENSMMUP00000024614 | ENSMMUP00000040739 | Interleukin 1 receptor associated kinase 1. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.971 |
IRAK1 | IRAK4 | ENSMMUP00000024614 | ENSMMUP00000000286 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase 4. | 0.999 |
IRAK1 | MAP3K7 | ENSMMUP00000024614 | ENSMMUP00000033340 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7. | 0.974 |
IRAK1 | MAVS | ENSMMUP00000024614 | ENSMMUP00000022556 | Interleukin 1 receptor associated kinase 1. | Mitochondrial antiviral-signaling protein isoform 1. | 0.940 |
IRAK1 | MYD88 | ENSMMUP00000024614 | ENSMMUP00000001339 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.999 |
IRAK1 | SQSTM1 | ENSMMUP00000024614 | ENSMMUP00000033598 | Interleukin 1 receptor associated kinase 1. | Sequestosome 1. | 0.695 |
IRAK1 | TAB1 | ENSMMUP00000024614 | ENSMMUP00000015873 | Interleukin 1 receptor associated kinase 1. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. | 0.979 |
IRAK1 | TAB2 | ENSMMUP00000024614 | ENSMMUP00000019658 | Interleukin 1 receptor associated kinase 1. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. | 0.998 |
IRAK1 | TRAF5 | ENSMMUP00000024614 | ENSMMUP00000038268 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.597 |
IRAK1 | TRAF6 | ENSMMUP00000024614 | ENSMMUP00000024012 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.999 |
IRAK4 | IKBKG | ENSMMUP00000000286 | ENSMMUP00000040739 | Interleukin-1 receptor-associated kinase 4. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.996 |