STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (810 aa)    
Predicted Functional Partners:
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
  
  
0.989
PLAU
Plasminogen activator, urokinase.
  
  
0.977
C3
Uncharacterized protein.
   
 0.951
HRG
Histidine rich glycoprotein.
   
 0.950
F12
Coagulation factor XII.
   
0.942
KLKB1
Kallikrein B1; Belongs to the peptidase S1 family.
  
 
0.938
ENSMMUP00000017083
Ig-like domain-containing protein.
    
  0.914
SERPINF2
Serpin family F member 2; Belongs to the serpin family.
   
 0.912
LOC106999628
Ig-like domain-containing protein.
    
  0.911
SERPINC1
Antithrombin III; Belongs to the serpin family.
   
 0.910
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.