STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GALCGalactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. (685 aa)    
Predicted Functional Partners:
ASAH1
N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family.
   
 
 0.976
UGT8
UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family.
     
 0.976
ARSA
Arylsulfatase A.
   
 
 0.969
SMPD1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.
     
 0.951
GBA
Glucosylceramidase.
     
 0.951
GLA
Alpha-galactosidase.
   
 
 0.938
CERS2
LAG1 longevity assurance homolog 2.
   
 
 0.929
GBA2
Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
     
 0.928
CERK
Ceramide kinase.
     
 0.922
ASAH2
Neutral ceramidase.
     
 0.920
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (38%) [HD]