| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DUSP6 | MAPK1 | ENSMMUP00000066425 | ENSMMUP00000016444 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.994 |
| DUSP6 | MAPK3 | ENSMMUP00000066425 | ENSMMUP00000053373 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.995 |
| JUN | MAP2K1 | ENSMMUP00000074392 | ENSMMUP00000022140 | Transcription factor AP-1; Belongs to the bZIP family. | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | 0.508 |
| JUN | MAPK1 | ENSMMUP00000074392 | ENSMMUP00000016444 | Transcription factor AP-1; Belongs to the bZIP family. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.991 |
| JUN | MAPK3 | ENSMMUP00000074392 | ENSMMUP00000053373 | Transcription factor AP-1; Belongs to the bZIP family. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.989 |
| JUN | TP53 | ENSMMUP00000074392 | ENSMMUP00000011334 | Transcription factor AP-1; Belongs to the bZIP family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.833 |
| MAP2K1 | JUN | ENSMMUP00000022140 | ENSMMUP00000074392 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | Transcription factor AP-1; Belongs to the bZIP family. | 0.508 |
| MAP2K1 | MAP2K2 | ENSMMUP00000022140 | ENSMMUP00000069781 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.999 |
| MAP2K1 | MAPK1 | ENSMMUP00000022140 | ENSMMUP00000016444 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.997 |
| MAP2K1 | MAPK3 | ENSMMUP00000022140 | ENSMMUP00000053373 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.998 |
| MAP2K1 | TP53 | ENSMMUP00000022140 | ENSMMUP00000011334 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.440 |
| MAP2K2 | MAP2K1 | ENSMMUP00000069781 | ENSMMUP00000022140 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | 0.999 |
| MAP2K2 | MAPK1 | ENSMMUP00000069781 | ENSMMUP00000016444 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.994 |
| MAP2K2 | MAPK3 | ENSMMUP00000069781 | ENSMMUP00000053373 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.990 |
| MAPK1 | DUSP6 | ENSMMUP00000016444 | ENSMMUP00000066425 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.994 |
| MAPK1 | JUN | ENSMMUP00000016444 | ENSMMUP00000074392 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Transcription factor AP-1; Belongs to the bZIP family. | 0.991 |
| MAPK1 | MAP2K1 | ENSMMUP00000016444 | ENSMMUP00000022140 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. | 0.997 |
| MAPK1 | MAP2K2 | ENSMMUP00000016444 | ENSMMUP00000069781 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.994 |
| MAPK1 | MAPK3 | ENSMMUP00000016444 | ENSMMUP00000053373 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.999 |
| MAPK1 | PTPN7 | ENSMMUP00000016444 | ENSMMUP00000018133 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Protein tyrosine phosphatase non-receptor type 7. | 0.994 |
