node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASIP | DCT | ENSMMUP00000077604 | ENSMMUP00000036155 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Dopachrome tautomerase. | 0.553 |
ASIP | MC1R | ENSMMUP00000077604 | ENSMMUP00000032257 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). | 0.939 |
ASIP | OCA2 | ENSMMUP00000077604 | ENSMMUP00000015778 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | OCA2 melanosomal transmembrane protein. | 0.715 |
ASIP | SLC24A5 | ENSMMUP00000077604 | ENSMMUP00000024781 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.654 |
ASIP | SLC45A2 | ENSMMUP00000077604 | ENSMMUP00000034889 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 45 member 2. | 0.700 |
ASIP | TYR | ENSMMUP00000077604 | ENSMMUP00000014548 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Tyrosinase. | 0.728 |
ASIP | TYRP1 | ENSMMUP00000077604 | ENSMMUP00000071668 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Tyrosinase related protein 1. | 0.738 |
DCT | ASIP | ENSMMUP00000036155 | ENSMMUP00000077604 | Dopachrome tautomerase. | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | 0.553 |
DCT | MC1R | ENSMMUP00000036155 | ENSMMUP00000032257 | Dopachrome tautomerase. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). | 0.571 |
DCT | OCA2 | ENSMMUP00000036155 | ENSMMUP00000015778 | Dopachrome tautomerase. | OCA2 melanosomal transmembrane protein. | 0.492 |
DCT | SLC24A5 | ENSMMUP00000036155 | ENSMMUP00000024781 | Dopachrome tautomerase. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.647 |
DCT | TYR | ENSMMUP00000036155 | ENSMMUP00000014548 | Dopachrome tautomerase. | Tyrosinase. | 0.788 |
DCT | TYRP1 | ENSMMUP00000036155 | ENSMMUP00000071668 | Dopachrome tautomerase. | Tyrosinase related protein 1. | 0.939 |
EDA2R | EDAR | ENSMMUP00000019702 | ENSMMUP00000036157 | Ectodysplasin A2 receptor. | Ectodysplasin A receptor. | 0.411 |
EDA2R | SLC24A5 | ENSMMUP00000019702 | ENSMMUP00000024781 | Ectodysplasin A2 receptor. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.673 |
EDA2R | SLC45A2 | ENSMMUP00000019702 | ENSMMUP00000034889 | Ectodysplasin A2 receptor. | Solute carrier family 45 member 2. | 0.667 |
EDAR | EDA2R | ENSMMUP00000036157 | ENSMMUP00000019702 | Ectodysplasin A receptor. | Ectodysplasin A2 receptor. | 0.411 |
EDAR | SLC24A5 | ENSMMUP00000036157 | ENSMMUP00000024781 | Ectodysplasin A receptor. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.828 |
EDAR | SLC45A2 | ENSMMUP00000036157 | ENSMMUP00000034889 | Ectodysplasin A receptor. | Solute carrier family 45 member 2. | 0.661 |
MC1R | ASIP | ENSMMUP00000032257 | ENSMMUP00000077604 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | 0.939 |