STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AANATSerotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. Belongs to the acetyltransferase family. AANAT subfamily. (248 aa)    
Predicted Functional Partners:
ASMT
Acetylserotonin O-methyltransferase; Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
   
 
 0.995
DDC
Aromatic-L-amino-acid decarboxylase.
     
 0.945
MAOA
Amine oxidase.
     
 0.933
MAOB
Amine oxidase.
     
 0.933
IDO2
Indoleamine 2,3-dioxygenase 2.
     
 0.929
IDO1
Indoleamine 2,3-dioxygenase 1.
     
 0.913
INMT
Uncharacterized protein.
     
 0.901
TPH1
Tryptophan hydroxylase 1.
   
  
 0.757
MTNR1B
Uncharacterized protein.
   
  
 0.741
ESCO2
Establishment of sister chromatid cohesion N-acetyltransferase 2.
   
  
 0.732
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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